Endocrine Abstracts

To investigate the best criteria and time to diagnose dysglycemia in β-TM patients, the ICETA performed a retrospective study on glycemic abnormalities (GD) in 397 with β-TM patients (aged 5–40 years; 56.3% males) followed between 1988 to 2021 in a single centre (by VDS) (40 years).Methods: Fasting blood glucose (FPG) and standard oral glucose tolerance test (OGTT) results were collected over 40 years of follow up and results were categori...

We studied retrospectively the changes of glucose-insulin homeostasis from early childhood to young adulthood in β-thalassemia major (β -TM) patients with impaired fasting glucose (IFG) vs those with normal OGTT.Methods: All data entered in the database of β -TM patients’ records from September 1983 to September 2021 were included in the study.Results: The occurrence of dysglycemia (GD)...

We assessed glycemia and insulin markers in 18 young children with beta thalassemia major (BTM). Insulin markers measured included: the Homeostatic Model Assessment index of insulin resistance (HOMA-IR), Matsuda index (MI), the insulinogenic index (IGI), and the oral disposition index (oDI). 9 had normal fasting glucose (FG) and 9 had impaired fasting glucose (IFG)Results: HOMA-IR, a marker of IR was significantly higher in children with BTM compared to ...